Hormone Fluctuations and Mood Biology

Welcome to this week’s Midlife Minute episode.

We’re focusing on the importance of having good mental health today. Statistics show that women are experiencing increased anxiety, depression, insomnia, and even suicidal thoughts during midlife, yet the stigma around mental health remains surprisingly strong.

Join me as I explore the science behind this, why it’s happening, and the importance of empowering yourself to demand better care.

IN THIS EPISODE, YOU WILL LEARN:

• The issues that contribute to the midlife mental health challenges women are experiencing

• How sleep disruptions in perimenopause increase anxiety, depression, and irritability

• The metabolic and endocrine factors that can compound mood instability in midlife

• Why perimenopause is a neurological as well as reproductive transition

• The evidence-based benefits of HRT for supporting mental health

• The role of estrogen in brain function and emotional regulation

• Why HRT is especially important for women experiencing abrupt or early menopause

• Some practical guidance for using HRT to support mental health

Connect with Cynthia Thurlow  

• Follow on X, Instagram & LinkedIn

• Check out Cynthia’s website.

• Submit your questions to support@cynthiathurlow.com

• Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.

• Cynthia’s Menopause Gut Book is on presale now!

• Cynthia’s Intermittent Fasting Transformation Book

• The Midlife Pause Supplement Line

References:

Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial (https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2298235) 

Efficacy of Estradiol in Perimenopausal Depression: So Much Promise and So Few Answers (https://onlinelibrary.wiley.com/doi/10.1002/da.22391)

Effects of Hormone Therapy on Cognition and Mood (https://www.fertstert.org/article/S0015-0282(14)00178-2/fulltext)

Does Menopause Hormone Therapy Improve Symptoms of Depression? Findings From a Specialized Menopause Clinic 

A Meta-analysis of the Effect of Hormone Replacement Therapy upon Depressed Mood (https://www.sciencedirect.com/science/article/abs/pii/S0306453096000340?via%3Dihub)

The Effect of Hormone Replacement Therapy on Cognition and Mood (https://onlinelibrary.wiley.com/doi/10.1111/cen.14856)