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Ep. 52: “Lymphoma Immunotherapy” Featuring Dr. Joshua Brody

The Immunology Podcast

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The Role of TMB in Anti-Pd1 Response in Lymphoma and Breast Cancer

Tumor mutational burden TMB which is kind of a predictor not a great one for who will respond to anti-PD1 antibodies. In our small studies we can't show a clear correlation but there's just too small so far. We started with lymphoma breast partly for the practical reasons and partly because at least they do have decent tumor mutational burdensSo they both seem reasonable. We think it could be applied to a bunch of other types as well. So sounds like ongoing trial adding in the PD1 which makes a good next step.

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