The Role of Chondrocytes in Metaphesis

The proliferative zone is affected in the setting of a chondroplasia, gigantism, and multiple hereditary exostosis. The hypertrophic zone is involved in slipped capital femoral epiphesis or skiffy,. It's also affected in rickets, specifically the provisional calcification zone. In the primary spongiosa, there is vascular invasion and resorption of the transverse septa. Osteoblasts align on the cartilage bars produced by physeal expansion.