The body-fat thermostat and hormonal control

You are not eating because you are hungry. You are eating because you have been trained to, and the food industry designed it that way. This episode dismantles everything you thought you knew about hunger, weight loss, and metabolism, and gives you a science-backed framework to finally stop fighting your own biology. 

-Watch this episode on YouTube: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Jason Fung, a New York Times bestselling author, practicing nephrologist, and one of the most trusted voices in functional medicine and metabolic health. Dr. Fung completed medical school at the University of Toronto and a fellowship in nephrology at Stanford University. He is the author of multiple critically acclaimed books including The Obesity Code, The Diabetes Code, and his newest release The Hunger Code, and is the co-founder of The Fasting Method, a program designed to help people lose weight and reverse type 2 diabetes through fasting and real food nutrition. His work has helped millions break free from calorie restriction dogma for good. 

Together, Dave and Dr. Fung expose the three types of hunger driving the obesity epidemic, why calorie restriction fails almost every time, and what ultra-processed foods actually do to your brain's reward system. They get into the real science of fasting, metabolism, hormonal signaling, GLP-1 drugs, food addiction, conditioned eating behavior, and how your physical environment is quietly sabotaging your results. If you are serious about biohacking your hunger, optimizing your body composition, and taking control of your biology without white-knuckling willpower, this episode delivers the tools you need. 

This is essential listening for anyone focused on biohacking, longevity, human performance, fasting, metabolism, anti-aging, sleep optimization, brain optimization, functional medicine, and eating smarter not harder. 

You'll Learn: 

• Why calorie restriction fails and what actually controls how much you eat 
• The three types of hunger: homeostatic, hedonic, and conditioned, and how each one drives overeating 
• How ultra-processed foods hijack your dopamine system and destroy satiety signals 
• Why wiring your jaw shut or cutting your stomach still does not produce long-term weight loss 
• What GLP-1 drugs like Ozempic actually reveal about hunger, metabolism, and the body fat thermostat 
• How conditioned hunger works like Pavlov's dogs and practical strategies to reverse it 
• The role of your physical environment in controlling food noise and cravings 
• Why food addiction is real, and which foods are engineered to keep you hooked 
• How fasting resets hunger signals, improves metabolic flexibility, and supports ketosis 
• The mindset shift that makes healthy eating feel effortless instead of like deprivation 

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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Jason Fung, The Hunger Code, fasting, intermittent fasting, hunger, food addiction, ultra-processed foods, calorie restriction, weight loss, obesity, type 2 diabetes, metabolism, insulin, leptin, hedonic hunger, conditioned hunger, food noise, GLP-1, Ozempic, dopamine, satiety, body fat thermostat, food environment, behavioral psychology, real food 

Resources:   

• Check out all of Dr. Fung’s books and content at: https://www.doctorjasonfung.com/ 

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• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

0:00 – Trailer 

1:01 – Introduction 

2:29 – The 3 Types of Hunger 

4:41 – Conditioned Hunger 

6:51 – Ultra-Processed Foods 

11:47 – Dave's Personal Story 

14:06 – The Calorie Debate 

16:32 – Restricting Calories Doesn't Work 

18:38 – The 3 Whys Framework 

20:21 – Shame in Weight Loss 

25:05 – GLP-1 Drugs 

27:53 – Ranking the 3 Hungers 

33:43 – Food Addiction 

38:31 – Fake Fats & Fake Sweeteners 

45:03 – 3 Golden Rules for Weight Loss 

47:42 – Deprogramming Hunger 

50:36 – Pavlok & Behavior Hacking 

59:26 – Outro 

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