Key Biomarkers to Track

Shah names essential tests—HbA1c, fasting insulin, hsCRP, ApoB, hormones—and explains target ranges and why they matter.

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Episode notes

In this episode of the WHOOP Podcast How To Series, WHOOP Global Head of Human Performance and Principal Scientist, Dr. Kristen Holmes, sits down with renowned longevity expert, Dr. Darshan Shah, to break down how to maximize longevity. The episode focuses on what truly drives healthspan, drawing from Dr. Shah’s own experience as a trauma surgeon. Dr. Shah explains why most chronic diseases are preventable and reversible and why lasting change comes from mastering the fundamentals: sleep quality, daily movement, nutrition, stress management, and consistent data tracking. The conversation explores key biomarkers, the dangers of sedentary living, the role of toxins and environment, and the importance of habit formation, purpose, and emotional health. Together, Dr. Shah and Dr. Holmes reframe longevity not as living longer, but as living better— extending vitality, resilience, and performance throughout life.

(00:47) Intro to Dr. Darshan Shah, Longevity Expert

(01:14) How Chronic Illness Impacted Dr. Shah Firsthand

(06:15) Dr. Shah: From Trauma Surgeon to Longevity Focused Lifestyle

(09:30) Building Next Health: Dr. Shah’s Impact on the Longevity World

(13:10) Biggest Barrier For Patients: What Trends Dr. Shah Is Seeing

(19:50) The Influence of a Morning Routine on Health and Longevity

(21:36) Looking At The Biggest Game Changer: Movement Throughout The Day

(24:26) Eliminating The “All or Nothing” Mentality

(28:23) Beyond Sedentary Behavior: Habits Declining Longevity

(37:18) Best Biomarkers Promoting Longevity

(48:04) Optimization Beyond Nutrition, Sleep, and Exercise (Advanced Advice)

(52:28) Combatting Trauma and Understanding The Nervous System