Would You Still Use the Web Upsettings in a Web Application?

For anything else than a web application, you would typically use the upsettings that o mentioned. The other one is a more distributed configuration store called key vaults. You can set that up as a service and put whatever confit values you need in there. And then you have all your apts. If you have ten web aps, doesn't matter if they need to read the same kind of information or configuration data, you can do that from some kind of distributed configration store.