Anaesthesia Coffee Break cover image

Speed of onset of local anaesthetics and another textbook correction!

Anaesthesia Coffee Break

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Is There Any Barrier to Diffusion?

The transmission of signals there primarily via depolarization via voltage gated sodium channels. The key point here is that it's the free drug that penetrates the nerve into the nerve. And when we're talking about into the nerve, there's a couple of layers that you want to know about. Now, I think that the key points here are going to be solubility and pKa.

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