Guidelines for Tetanus Prophylaxis

Gustilo type 1 and 2 injuries receive a first generation cephalosporin or klindamycin or vancomycin. For gustilo type 3 wounds, use an amino glycoside. Toxoid and immunoglobulin should be given intramuscularly with two different syringes in two different locations. Remember the guidelines for tetanus prophylaxis depend on three factors: Complete or incomplete vaccination history, date of most recent vaccination, and severity of wound.