Under Secretary Darío Gil joins Navin Girishankar to discuss the Genesis Mission—a Department of Energy–led initiative to build an AI-driven platform for accelerating scientific discovery. Under Secretary Gil outlines the Mission's integration of AI, supercomputing and quantum technologies for scientific exploration, alongside institutional innovations such as public-private partnerships and interagency coordination. He also addresses research security, allied collaboration, and the long-term vision to revitalize the U.S. science and technology enterprise.