Decera Clinical Education Oncology Podcast cover image

Expert Insight on New Data From SGO 2023 Informing Treatment for Endometrial, Cervical, and Ovarian Cancers

Decera Clinical Education Oncology Podcast

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The Effects of a Priming Dose on Tumor Growth

The first study was a randomized phase two trial essentially the same population of patients but in this case the drug was different it was pembrolyzumab. In arm A they got a so-called priming dose and this seemed to result in an early systemic expansion of tumor associated T cell clones while in the non-priming arm there was a tumor associated T Cell clone contraction. So that's hypothesis generating really but it can help us in study design moving forward as we continue to look at this idea of moving immunotherapy into the frontline for locally advanced cervical cancer.

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