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Toxidromes; Roadside to Resus

The Resus Room

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Flumazenil and Seizures

The concerns are directly related to flumazenil's mechanism of action. The rapid and complete reversal of the benzos diazepine action can then result in seizures and agitation. In addition to that badness, often deliberate overdoses involve multiple agents and some of those may have pro-convulsant effects. And so the benzo is actually having a positive antagonistic effect on that kind of pro- Convulsant effect of the other medicines.

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