Pharmacokinetic Principles of Local Anesthetics using Rope-Pivacane and Lignacane

This chapter delves into how pharmacokinetic principles impact the onset and duration of action of local anesthetics, using ropivacaine and lidocaine as case studies. It covers the movement of drugs from the interstitium to the axoplasm during onset and from the axoplasm back to the interstitium during offset, highlighting key factors that affect speed and duration.