Fasting Research: Humans vs Rodents

Zone two has been sold to you as the gold standard for mitochondrial health, fat burning, and longevity. But what if it was built on culture, not science. In this episode, I sit down with Kristi Storoschuk, a PhD researcher whose work is challenging some of the biggest claims in the exercise world right now. We break down why zone two training lacks the scientific evidence everyone assumes it has, why higher intensity zones three and four are actually more potent for mitochondrial adaptation, and why the 80/20 training split from elite athletes was never designed for someone exercising four days a week. We also get into why fasting doesn't activate the same cellular pathways in humans as it does in rodents, why cortisol from exercise is not the same as chronic stress, the truth about fasted exercise for women, and what lactate actually tells us about our metabolic health. Kristi also shares her current research in collaboration with Dr. Andy Galpin and Dr. Tommy Wood on whether lactate threshold can serve as a non-invasive proxy for mitochondrial content. This conversation will completely change how you think about every cardio session you've ever done.

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TOPICS DISCUSSED

00:00 Intro: Was Zone Two Built on Culture, Not Science?

03:19 The Three Exercise Intensity Domains (Not Five Zones)

08:00 Zone Two and Fat Burning: What the Research Actually Shows

12:00 Why Women Are Being Scared Away from Zone Three and Four

20:45 Fasting in Rodents vs. Humans: The Research That Changed Everything

24:00 Fasted Exercise and Cortisol: The Real Story for Women

29:00 What Lactate Actually Tells Us About Mitochondrial Health

37:00 VO2 Max, Mitochondria, and Longevity

43:30 Exercise as Your Daily Metabolic Reset

49:00 The Best Cardio Prescription for Healthspan

55:30 How a 73 Year Old Should Think About High Intensity

58:00 How to Know What Zone You're In Without a Monitor

01:02:00 Sex Differences in Exercise: What the Data Actually Says

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I’m Louisa Nicola - clinical neurophysiologist - Alzheimer’s prevention specialist - founder of Neuro Athletics.

My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention.

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