Off-Label Uses and Addiction Signals

We are living through one of the most significant shifts in medicine in generations, and most people don’t fully understand what it means. Dr. Christle Guevarra joins me to zoom out on the entire GLP-1 landscape; from the drug’s origins as a modest diabetes treatment in 2005 to today’s third-generation medications still moving through clinical trials, and what all of it means for the future of obesity, performance, and longevity.

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⏰Timestamps:

00:00 Intro of Show

06:48 Changes in the Fat Loss Landscape

06:54 Engagement in Competitive Powerlifting

11:29 Perspectives on GLP-1 Medication

26:10 Perimenopause Journey

27:13 Topamax

28:03 Urosepsis

30:23 Weight Loss Programming

31:43 Patients' Decision to Take GLP-1

37:44 Risks and Effects on Taking GLP-1

38:10 Pancreatitis

41:40 Fen-Phen (Fenfluramine/phentermine) / Ephedra

45:59 Who Should Not Take GLP-1?

49:24 Proper Nutrition to Support Taking GLP-1

52:14 Recommendation for the New Dietary Guidelines

59:01 Residency and Sports Medicine Fellowship

1:02:38 Are Athletes Recommended to Take GLP-1?

1:08:49 Lack of Randomized, Controlled Trials for Peptides

1:10:38 Key Take-away's from Dr. Christle

1:13:24 Should Women Weigh Themselves?

1:21:02 Should Women Lift Weights?

1:21:55 What's Next for Dr. Christle?

‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

This episode includes paid sponsorships.