Automating research: Karpathy's agent experiments

This week we sit down with three founders building at the frontier of AI in space, autonomous hardware, and software reliability: Philip Johnston (StarCloud), Boris Sofman (Bedrock Robotics), and Spiros Xanthos (Resolve AI). We dig into why data centers are heading to orbit, how AI is taking the wheel on construction sites, and whether the industry is moving too fast for its own good.

We explore how physical infrastructure, real-world autonomy, and AI trust are reshaping the industry from the ground up.

• Sam Altman vs. Space Data Centers: He said it won't matter "this decade." But Philip breaks down why the economics of space compute are about to flip.
• The Construction Labor Crisis: Half the skilled workforce is retiring in the next seven years while data center construction spend hits $700B this year alone. Boris explains why autonomous excavators aren't replacing workers, they're the only way to keep up.
• AI Broke Amazon's Code: Generative AI is shipping software faster than engineers can understand it. Spiros warns that accelerating code velocity without upgrading reliability is a disaster waiting to happen.
• Automation Bias & Skill Degradation: What aviation taught us about over-trusting autopilot, and what developers need to learn fast.
• Why Americans Don't Trust AI: A KPMG survey puts AI's favorability between ICE and Iran. The panel debates whether healthcare, education, and construction are the three wins that could turn the tide.
• Karpathy's AI Research Agent: A weekend project that fires off entire teams of AI grad students running experiments overnight. Is this what automating the scientific method actually looks like?
• Anthropic vs. the Pentagon: The U.S. government threatened to label a leading domestic AI company a supply chain risk. Who gets to decide how AI is used in warfare?

Timestamps:

00:00 — Welcome to This Week in AI: Episode 4

01:22 — Philip Johnston (Star Cloud): Why data centers in space will dominate

03:35 — Boris Sofman (Bedrock Robotics): Autonomizing construction equipment with AI

08:44 — Spiros Santos (Resolve AI): Intro & AI-generated code's "high blast radius" problem at Amazon

09:31 — Squarespace: Turn your idea into a beautiful website! Go to http://www.squarespace.com/twist for a free trial. When you’re ready to launch, use offer code TWIST to save 10% off your first purchase of a website or domain.

10:35 — Deep dive: Amazon's code red meetings & trusting AI-generated code too much

13:20 — Automation bias & skill degradation: the aviation autopilot analogy

17:09 — Why Americans distrust AI: and what the industry should do about it

20:05 — Notion ad

21:29 — KPMG survey results: only 9% of large companies plan job cuts from AI, 55% plan to hire more; panel debates job displacement fears

31:43 — AI's PR fix: healthcare, education & construction as the big three wins

39:22 — World models & humanoid robots: LeCun's $1B bet & the Figure video controversy

47:59 — Star Cloud's 88,000-satellite constellation: economics of space compute

56:05 — Andrej Karpathy's AI research agent: automating the scientific method

1:01:04 — Anthropic vs. the military: supply chain risk, Dario's dilemma & the Iran strike claim

1:07:50 — Hiring pitches & outro: Star Cloud, Bedrock Robotics, Resolve AI

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