Microbiome, Neurotransmitters, and Vagal Tone

When living with Ehlers-Danlos Syndrome and hypermobility disorders, medications alone rarely resolve all the symptoms. In this episode of Bendy Bodies, Dr. Linda Bluestein is joined by Dr. Ina Stephens, integrative medicine specialist and Associate Medical Director of the UVA Health EDS and Hypermobility Disorders Center, for a wide-ranging conversation about how lifestyle medicine, nervous system regulation, and whole-body care can dramatically influence outcomes for people with connective tissue disorders.
Dr. Stephens explains how her background in infectious disease, vaccinology, and complex care led her to recognize patterns across seemingly unrelated symptoms and why listening deeply to patients often reveals the underlying problem. The discussion explores how nutrition, gut health, vagal nerve tone, sleep quality, and gradual strength building all influence inflammation, fatigue, and autonomic dysfunction in EDS.
The episode also dives into the science of the microbiome, why small lifestyle shifts can produce meaningful physiologic change, and how integrative medicine expands the treatment toolbox beyond traditional Western approaches. For patients navigating complex symptoms, and clinicians caring for them, this conversation offers a thoughtful reminder that healing often happens through steady, strategic steps rather than quick fixes.

Takeaways:

There is rarely a single “magic” treatment for EDS, POTS, or MCAS.  Progress usually comes from strategic sequencing.

Overtreating symptoms without addressing underlying patterns can create long-term setbacks.

Physical therapy must be individualized in hypermobility, with an emphasis on pacing and trust.

Shared decision-making improves outcomes, especially when treatment goals align with what brings the patient meaning and quality of life.

Minimally disruptive medicine matters, reducing cognitive, financial, and physical treatment burden is part of effective care.

Find the episode transcript here.

Want to learn more about the UVA EDS Center?

For Appointments and Questions: RUVAEDSCenter@uvahealth.org

UVA EDS: https://www.uvahealth.com/healthy-practice/advancing-care-through-ehlers-danlos-clinic

UVA EDS FAQ: https://www.uvahealth.com/support/eds/faq

UVA Pediatric Integrative Medicine: https://childrens.uvahealth.com/specialties/integrative-health

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