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Speed of onset of local anaesthetics and another textbook correction!

Anaesthesia Coffee Break

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How to Calculate PK of Licknacane

Stan: I think we're all a bit relieved that you're not going to be tested on some pretty maths, as much as we all love maths. But if you were to remember anything, if you had a bit of extra brain space, this is a formula for ionized fraction of bases,. And then that's the thing to remember if anything. So let's use an example now of Licknacane. Let's just use 7.9 just because it's easy. All right. Now we've got pH is 7.4, and your pKa of Lick nacane is 7.9. If we do that, that is 10 to the power of minus

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