In this discussion at the College of Intensive Care meeting in Tasmania 2025, Peter Brindley and Leon Byker engage with Prof. John Myburgh, who talks about his long-standing involvement in critical care research and the annual college meeting. John discusses the significance of the grad ceremony and highlights the impact of his research group at the George Institute. He reflects on the contributions of late colleague Ronaldo and praises current leading figures. The conversation delves deep into the ongoing research on steroids in critical care, focusing on genetic endotypes and precision medicine. Other topics covered include interleukin treatments, the evolution of fluid management in treating conditions like diabetic ketoacidosis, and the adaptive platform trials in sepsis. The discussion concludes with reflections on the Queensland Covid-19 vaccine and the broad implications of science, social forces, and politics in critical care advancements.00:00 Welcome and Introductions00:32 John's Involvement with the College01:47 Research and Collaborations03:29 Steroids in Critical Care04:49 Genomic Studies and Future Trials07:18 Challenges in Measuring Outcomes13:27 Interleukins and Sepsis14:18 Fluid Management in Critical Care19:31 COVID-19 and the Queensland Vaccine23:49 Closing Remarks
