The Pathophysiology of Dupatren's Disease

type 3 collagen predominates in Dupatren's Disease way more than Type 1 collagen. Cytokines have been implicated specifically TGF-1, TGF-2, epidermal growth factor, PDGF, and connective tissue growth factor. Some ectopic manifestations to keep in mind include letter hose disease of the plantar fascia in 10-30% of patients with Dupatren’s Disease. Associated conditions with dupitrance disease include HIV, alcoholism, diabetes, and anti-seizure medications.