Diet, Microbiome, TMAO, and COVID

In this episode, Dr Laurence Sperling talks with Dr Kim Williams about preventive cardiology nutrition intervention as a key co-therapy for tackling dyslipidemia.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/958748). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals.

Resources

Exercise and CVD Mortality

Associations of specific types of sports and exercise with all-cause and cardiovascular-disease mortality: a cohort study of 80,306 British adults https://bjsm.bmj.com/content/51/10/812#T3

Diet and Dietary Patterns

The reasons for geographic and racial differences in stroke study: objectives and design https://pubmed.ncbi.nlm.nih.gov/15990444/

Heart disease and stroke https://www.cdc.gov/chronicdisease/resources/publications/factsheets/heart-disease-stroke.htm

Effects of ketogenic diets on cardiovascular risk factors: evidence from animal and human studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452247/

Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000000510

Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study https://www.thelancet.com/article/S0140-6736(17)32252-3/fulltext

Intensive lifestyle changes for reversal of coronary heart disease https://pubmed.ncbi.nlm.nih.gov/9863851/

Dietary adherence and acceptability of five different diets, including vegan and vegetarian diets, for weight loss: the New DIETs study https://www.sciencedirect.com/science/article/abs/pii/S147101531500080X

Guidelines and Population Studies

2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk https://academic.oup.com/eurheartj/article/41/1/111/5556353

TMAO

Trimethylamine-N-oxide (TMAO) predicts cardiovascular mortality in peripheral artery disease https://www.nature.com/articles/s41598-019-52082-z

Gut microbes impact stroke severity via the trimethylamine N-oxide pathway https://pubmed.ncbi.nlm.nih.gov/34139173/

Statin Adverse Effects

Effects of coenzyme Q10 on statin‐induced myopathy: an updated meta‐analysis of randomized controlled trials https://www.ahajournals.org/doi/10.1161/JAHA.118.009835

N-of-1 trial of a statin, placebo, or no treatment to assess side effects https://www.nejm.org/doi/full/10.1056/NEJMc2031173