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Ep. 48: “IMMUNOLOGY2023: Frontiers of Human Immunology” Featuring Drs. Mark Davis, Shruti Naik, and Daniel Mucida

The Immunology Podcast

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Is This TCR Going to Direct These Cells to the Prostate Again?

Some of these TCRs that are just repeated. So they're clearly generated and selected and escape thymic selection. When they take from this to wonder something, they focus on the 20 most prevalent. And they look at what happens if you take these 20 most prevalent TCRs and you start over again. They make mice that only that express those TCRs in the context of a bone marrow chimera.

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