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Speed of onset of local anaesthetics and another textbook correction!

Anaesthesia Coffee Break

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Lipoic Solubility With Local Anesthetics

Solubility is directly mentioned in a pixel of diffusion, whereas pKa is not. Are they both equally important or is one more important than the other? Great question. For local anesthetics here, it's the pKa that's going to be the most important because that determines the degree of ionization and ionization. And it's the unionization fraction that actually diffuses the cross. So why not solubility? I guess it's lipid solubility that they're specifically talking about when we talk about solubility of local anesthetic.

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