Gene Expression Study and SIRT1 Increase

Your skin is not just a cosmetic surface. It’s a living organ that responds to signals, and the right light signal can flip your biology into repair mode. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Get a discount from LYMA by using code ‘DAVE10’ at: https://lyma.life/ 

-Offer not valid on LYMA Laser PRO or LYMA Youth System

In this episode, Host Dave Asprey goes to London to meet Lucy Goff, founder of LYMA, at the LYMA headquarters. Lucy and her scientific team engineered a rare kind of at-home cold laser that delivers precise 808nm light with deep penetration, without burning, cutting, or “damaging to rebuild.” Their work is backed by published research in the Aesthetic Surgery Journal, and they’ve tested gene expression in human dermis, including a reported sixfold increase in SIRT1, a major longevity pathway. This is why you can trust this conversation. It’s not vibes, it’s engineering, biology, and data. 

Most “red light” products are basically glorified LEDs. They can be fine for the surface, but they do not deliver the kind of coherent, polarized, monochromatic light that your cells actually respond to in deep tissue. That matters because your mitochondria run the whole show. When mitochondria get a clean signal and more usable energy, your body suddenly has budget for repair, collagen, circulation, and recovery. That is the real mechanism behind anti-aging that does not rely on controlled injury. 

We get into how this kind of light hacking can change skin quality, muscle support under the skin, and even scars and fascia. We talk cartilage, knees, jowls, pigmentation, and the weird reality that you might not feel anything while it’s working. Dave also shares his early biohacking experiments using light for brain optimization, including the time he overdid it and temporarily scrambled his speech. That story will make you respect the power of light as a biological tool. 

We also talk human performance and travel. Dave breaks down how he uses light management for sleep optimization and jet lag, and why controlling light is as important as controlling food, fasting, ketosis, and metabolism. There’s also a practical angle here that most people miss: with AI, you can now take dense PubMed research and translate it into usable decisions without needing a PhD, which changes how fast you can learn, test, and personalize. 

If you care about longevity, neuroplasticity, recovery, and looking younger without trashing your tissue, this episode gives you a smarter way to think about lasers, supplements, nootropics, and the whole functional medicine stack. This is Smarter Not Harder biohacking, with a laser. 

You’ll Learn: 

• Why LED “red light therapy” is not the same as laser-based mitochondrial activation 

• How coherent light influences mitochondria, collagen quality, and anti-aging repair 

• What gene expression changes like SIRT1 suggest about longevity signaling 

• How light may support brain optimization, circulation, and neuroplasticity 

• Why scars and fascia can disrupt performance, and how light can support remodeling 

• How Dave uses light and lifestyle hacking for sleep optimization, travel, and metabolism 

• How AI makes research-driven biohacking more accessible and more personal 

Thank you to our sponsors!  

• KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off

• BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com

• fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.

• EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: cold laser therapy, 808nm laser, LYMA laser, infrared light therapy, red light vs laser, mitochondrial activation, SIRT1 gene expression, longevity biohacking, anti aging skin tech, collagen regeneration, fascia repair, scar healing laser, pigmentation removal light, brain optimization light therapy, neuroplasticity support, circulation enhancement, human performance recovery, functional medicine tools, Dave Asprey biohacking 

Resources:   

• LYMA Website (Use Code ‘DAVE10’ For A Discount: https://lyma.life/ 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

• 0:00 — LYMA Laser Origin 

• 1:20 — Dave’s Early Light Experiments 

• 5:15 — Laser vs LED 

• 10:54 — Safety and Diffusion Lens 

• 16:37 — 808nm and the Brain 

• 19:36 — Intimate Performance Effects 

• 26:03 — Knee Before and After 

• 29:25 — Vampire Bat and Veins 

• 37:36 — 6x SIRT1 Activation 

• 42:42 — Mitochondrial Signaling 

• 45:04 — Veins and Pigmentation 

• 52:14 — Scar Recovery 

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