Paternal age and sperm decline

Male fertility is declining, and most men have no idea why.

In this episode of The Dr. Gabrielle Lyon Show, Dr. Gabrielle Lyon sits down with Dr. Michael Eisenberg, Director of Male Reproductive Health at Stanford University and Chief Medical Advisor of SwimClub, to break down what truly determines sperm health and reproductive success.

They discuss:

1. How metformin, GLP-1 medications, testosterone therapy, and anabolic steroids affect male fertility
2. Why sperm count is a powerful biomarker for long-term health and longevity
3. The role of sleep, muscle mass, exercise, diet, marijuana, and environmental toxins like microplastics
4. Whether platelet-rich plasma, or PRP, can help severe male infertility
5. Daily habits that quietly reduce a couple’s chances of conceiving

If you care about fertility, hormones, metabolic health, or the future of men’s health, this conversation is essential.

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Find Dr. Michael Eisenberg at:

1. Eisenberg Lab: https://med.stanford.edu/eisenberglab.html
2. LinkedIn: https://www.linkedin.com/in/michael-eisenberg-9230a429
3. X: https://x.com/DrMEisenberg

Find Dr. Gabrielle Lyon at:

1. Instagram:@drgabriellelyon
2. TikTok: @drgabriellelyon
3. Facebook: facebook.com/doctorgabriellelyon
4. YouTube: youtube.com/@DrGabrielleLyon
5. X (Twitter): x.com/drgabriellelyon
6. Apply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/
7. Join my weekly newsletter – https://institute-for-muscle-centric-medicine.ck.page
8. Order my new book - https://www.amazon.com/exec/obidos/ASIN/1668085623

Chapters:

00:00 Sex habits, libido, GLP-1s, and what counts as male infertility

01:46 Metformin and male fertility, what the Denmark study found

07:27 How long sperm take to regenerate after meds, illness, or chemo

09:24 GLP-1 medications, weight loss, and semen quality in men

10:52 Testosterone therapy, anabolic steroids, and why sperm shuts down

16:41 Sperm as a vital sign, fertility as a window into long term health

19:14 Microplastics and environmental toxins found in semen

22:21 Paternal age and sperm quality, DNA fragmentation and pregnancy risk

26:03 Supplements and nutrients for sperm quality, what matters and why

30:00 Sex frequency, masturbation, libido, and fertility myths

35:38 Male infertility guidelines and medications that quietly lower fertility

48:41 Semen quality and future disease risk, diabetes, cancer, mortality

54:45 Anabolic agents, sperm banking, and how long frozen sperm lasts

1:04:14 PRP for severe male infertility, azospermia and real outcomes

1:16:41 New frontiers in male fertility, immune profiles, genomics, omics

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.