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Muscle Relaxants and their speed of onset

Anaesthesia Coffee Break

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The Pharmacokinetics of a Root Anesthesia

If your root administration is intramuscular, that's going to be slower than IV. You could also think about the site of injection. Is it in the foot or is it in central vein? That would definitely make a difference with that kind of distance. And then, yeah, volume of distribution. I mean, neuromuscular blocking drugs aren't really highly plasma protein bound, but still this is theoretically something that could be there.

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