Metformin, rapamycin and peptides

Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity Equation, and President and Founder of the American Board of Precision Medicine. He serves as Adjunct Professor at the George Washington University School of Medicine and CEO of the Institute for Human Optimization. Dr. Bajnath is certified through the Institute for Functional Medicine, board certified in anti-aging and regenerative medicine, and is one of the few clinicians actively applying genomics, transcriptomics, proteomics, and epigenetics together in a real clinical practice. 

Together, Dave and Dr. Bajnath break down why population-based medicine fails individuals, how functional medicine and precision science combine to unlock real human performance, and why your mitochondria sit at the foundation of every longevity strategy worth pursuing. They dig into how AI can help you decode your own inflammasome biology, why biohackers are using “sex drugs” to extend longevity, why vagal nerve stimulation directly suppresses the NLRP3 inflammasome, and which biomarkers like MMP9 and homocysteine mainstream medicine keeps ignoring. They also cover peptides, supplements, the dark side of metformin, microdosing for anti-aging, and why biohacking works best when it's personalized and precise. 

This is essential listening for anyone serious about longevity, smarter not harder health strategies, metabolism, sleep optimization, brain optimization, functional medicine, and taking full control of their biology. 

You'll Learn: 

• Why precision medicine outperforms population-based health strategies for human performance 
• How to layer genomics, transcriptomics, and proteomics into one complete biological picture 
• Which longevity biomarkers your doctor is likely ignoring, including MMP9 and homocysteine 
• How vagal nerve stimulation suppresses the NLRP3 inflammasome and drives anti-aging benefits 
• The real story on metformin, peptides, and which supplements actually move the needle 
• How AI can help you understand your own biology and act on it faster 
• Why biohacking precision beats random stacking every time 

Thank you to our sponsors!   

• Igniton | Head over to Igniton.com and use code DAVE for an exclusive 15% off your first order. 

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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: precision medicine, biohacking, Dave Asprey Cialis, Anil Bajnath, American Board of Precision Medicine, multi-omics, genomics, transcriptomics, proteomics, epigenetics, NLRP3 inflammasome, vagal nerve stimulation, MMP9, homocysteine, mitochondria, longevity, anti-aging, peptides, BPC-157, metformin, rapamycin, functional medicine, human performance, supplements, EGCG, exposome, nitric oxide, vascular health, metabolism, brain optimization, AI health, biohacking technology, Dave Asprey Sex Drugs 

Resources:   

• Learn More About Anil’s Work And the Institute For Human Optimization At: https://ifho.org/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Trailer 

00:53 – Intro to Precision Medicine 

01:58 – Dr. Bajnath's Holistic Health Journey 

05:03 – Pharmaceuticals vs. Supplements 

07:58 – Peptides and Longevity Molecules 

10:34 – Sexual Health and Vitality 

13:56 – Vascular Health and Blood Flow 

15:14 – Multi-Omics Approach 

19:03 – DNA and Genomics 

22:17 – Transcriptomics and RNA 

24:24 – Proteomics and Inflammation Markers 

32:00 – The Human Exposome 

34:55 – Key Health Biomarkers 

36:58 – Cell Membrane Dynamics 

40:28 – Biological Investment Strategy 

41:53 – Life Extension Possibilities 

48:52 – Bioenergetics and Mitochondria 

49:47 – Quantum Medicine and the Future 

51:33 – Vagal Nerve Stimulation 

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