Psychedelics challenge the biochemical model

From Krista:

The word “trauma” is used so widely at present, arguably too widely. But it bespeaks a tenor of our shared reality. This episode is a journey inside what I've come to see as a parallel universe unfolding, where our species is unlocking knowledge about ourselves and capacities for radical healing of the most extreme trauma and distress. These findings are even giving rise to dramatic healing alliances across political and social lines that are inflamed in the culture at large. 

At universities and research laboratories around the U.S. and the world, there are countless clinical studies, yielding results it’s hard not at times to call miraculous — for complex PTSD, long-term addiction, treatment-resistant depression. What I’m talking about are therapeutically-administered treatments with plant medicines and chemical compounds we call psychedelic or empathogenic.

Use those words, and many of us — including me until not that long ago — might become wary. Like all forces of great power, these can cut in every direction — the dark and the light of the human condition. But the conversation you are about to hear, with one of the leading neuroscientists in this field, revolves around serious, important research in settings designed for careful, beneficial human effect. Gül Dölen's groundbreaking contribution to all of us is in her fascinating insight into what psychedelically-assisted therapies are revealing about the workings of the human brain and the brain's capacity to change and the human capacity for major transformation altogether. The potential consequences of this science are intimate and civilizational at once. I see them as a stunning ray of hope in a struggling world.

I interviewed Gül Dölen at the 2025 Aspen Ideas Festival.

Find an excellent transcript of this show, edited by humans, on our show page.

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Gül Dölen leads the Dölen Lab at U.C. Berkeley, where she is a Professor and the Bob & Renee Parsons Endowed Chair in the Department of Neuroscience and the Department of Psychology at the Berkeley Center for the Science of Psychedelics and the Helen Wills Neuroscience Institute. She also maintains an Adjunct Professorship in Neuroscience and Neurology at the Johns Hopkins University, School of Medicine. 

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