Toxidromes; Roadside to Resus
The Resus Room
00:00
Differentiating Between Serotonin Syndrome and Anti-Colonergic Toxicity
The sympathetic post-ganglionic muscarinic receptors are usually adrenergic rather than colonergic. The sweat glands are an exception as sympathetic fibers are colonergic, so this essentially explains why in anti-colonergic poisoning, the skin is always dry. However, in serotonin syndrome, the skin will be wet and the patient will be diaphragtic. Another thing to look for is with serotonin syndrome, you can get muscle rigidity and hyperreflexia,. We tend to see normal muscle tone and normal reflexes when we're treating these two syndromes.
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