Happy marrows are all alike; every unhappy marrow is unhappy in its own way. When haematopoiesis behaves itself, it’s frankly quite boring. When it goes rogue, it can get very creative. Join Cale, Bash and Nick as they attempt to walk through how this process goes off the rails, how MDS and AML are best understood and how dysplasia, cytopenias, blasts and clones all fit together.
TIMESTAMPS
0:55 - Our serious introduction to counterbalance last week
1:58 - Episode overview
2:50 - Introducing MDS
7:12 - Risk factors for MDS
8:53 - MDS progression
11:13 - Complications of MDS
13:10 - Leukaemic transformation
15:37 - MDS epidemiology
16:27 - Diagnosing MDS
21:19 - What is dysplasia?
26:44 - What we test on marrow
35:13 - Clonality assessment in MDS
42:29 - Caveats in diagnosing MDS
43:18 - MDS summary (finally)
44:09 - MDS treatment in brief
45:37 - Intro to AML
51:32 - Episode summary
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