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Ep. 48: “IMMUNOLOGY2023: Frontiers of Human Immunology” Featuring Drs. Mark Davis, Shruti Naik, and Daniel Mucida

The Immunology Podcast

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T-Recablation Detection of TCRs in Mice

Four of the 20 TCRs found to be self-reactive are already proliferating. If you co-culture them with spleenocytes from germ-free mice, they get activated when presented with self antigen basically. When upon T-recablation, these cells enrich, are enriched again in prostate and they produce interferon gamma. They have this T follicular helper phenotype in the spleen, but they lose some of these markers when they infiltrate the prostate under non-terecant conditions.

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