GLP-1s: effects on appetite and microbiome

Colorectal cancer is now the No.1 cause of death for people under 50 in the United States. When it is caught early, nine out of ten people survive. When it is caught late, only two out of ten do. Yet most people are not screening, not eating enough fiber, and have no idea how rapidly the gut microbiome is collapsing in modern populations.

I sat down with Dr. Karan Rajan, NHS surgeon, gut health expert, and founder of Loam Science, to break down the real biology behind the gut microbiome and why it may be one of the most powerful levers we have for longterm health. We cover the rising colorectal cancer epidemic in young people, why fiber is the single most important thing you can do for your colon, and how the microbiome connects to your brain, heart, hormones, immune system, and even your skin.

Dr. Karan also explains how stress, poor sleep, NSAIDs, antibiotics, and proton pump inhibitors silently destroy the gut lining, why the carnivore diet starves your microbiome, the emerging link between gut health and endometriosis, and what the science actually says about microbiome testing, GLP-1 peptides, and supplement quality.

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TOPICS DISCUSSED

00:00 Colorectal Cancer Is Now the #1 Killer Under 50

01:24 Why Early Screening Changes Everything

03:19 The Gut Microbiome Explained Simply

05:51 Why Fiber Is the Rent for Your Colon

11:32 The Hadza Tribe and What 100g of Fiber a Day Does

18:45 The Carnivore Diet and What It Does to Your Gut

24:10 Stress, the Vagus Nerve, and Gut Dysfunction

31:20 Sleep, Circadian Clocks, and Your Bowel Health

33:06 The Gut-Cancer Connection

34:12 Cholesterol, the Gut-Heart Axis, and LDL

38:50 Estrogen, Perimenopause, and the Microbiome

43:15 Endometriosis and the Microbiome Trial

48:30 Leaky Gut, NSAIDs, Antibiotics, and PPIs

53:25 GLP-1 Peptides, Semaglutide, and What the Research Says

55:38 Why Supplement Quality Is Mostly Unregulated

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I’m Louisa Nicola - clinical neurophysiologist - Alzheimer’s prevention specialist - founder of Neuro Athletics.

My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention.

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