Nicotine: Acute Boosts and Long-Term Tradeoffs

Your brain is aging faster than it should, and most of the decline is self-inflicted. Neuroscientist Dr. Tommy Wood reveals the exact mechanisms driving cognitive decay, and the biohacking strategies backed by hard science that can stop it, reverse it, and future-proof your brain at any age. 

-Watch this episode on YouTube: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Tommy Wood, one of the most credentialed minds working at the intersection of brain optimization, human performance, and longevity. Dr. Wood holds a medical degree from the University of Oxford, a PhD in physiology and neuroscience from the University of Oslo, and serves as Associate Professor of Pediatrics and Neuroscience at the University of Washington School of Medicine. He has published over 100 scientific papers, consulted with Olympians and world champions across more than a dozen sports, and worked directly with Formula 1 drivers to sustain elite focus and reaction time at 200 miles per hour. His forthcoming book, The Stimulated Mind: Future-Proof Your Brain from Dementia and Stay Sharp at Any Age, is the culmination of decades of research and real-world application. 

Together, Dave and Dr. Wood dismantle the myth that cognitive decline is inevitable, exposing how societal expectations become self-fulfilling prophecies and how the tools of biohacking, including sleep optimization, neuroplasticity training, nootropics, supplements, and strategic exercise, can dramatically shift your brain's long-term trajectory. They dig into the 3S Model of brain health (Stimulus, Supply, Support), the Yerkes-Dodson arousal curve and what it means for focus and flow states, and the surprising truth about AI, boredom, and what actually happens to your brain when you let ChatGPT do your thinking for you. 

This episode is essential listening for anyone serious about anti-aging, brain optimization, functional medicine, metabolism, human performance, and getting smarter without working harder. 

You'll Learn: 

• Why cognitive decline is largely a self-fulfilling prophecy driven by expectation, not biology 
• How the 3S Model (Stimulus, Supply, Support) determines your brain's long-term health and resilience 
• What Formula 1 drivers teach us about arousal, flow states, and peak cognitive performance 
• Why high-intensity interval training produces dramatically greater neuroplasticity benefits than Zone 2 cardio alone 
• How creatine, nicotine, nootropics, and other supplements actually affect the aging brain 
• The real data on alcohol, dementia risk, and what "occasional drinking" actually means scientifically 
• How to use AI tools like ChatGPT in a way that builds brain function instead of destroying it 
• Why boredom is a neurological necessity and how chronic low-level stimulation is quietly eroding your cognition 
• What mitochondria and lactate signaling have to do with BDNF and long-term memory 
• How resistance training, coordinative movement, and blood flow restriction each deliver separate and distinct cognitive benefits 

Thank you to our sponsors!      

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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Tommy Wood, The Stimulated Mind, brain health, cognitive decline, dementia prevention, neuroplasticity, brain optimization, biohacking, Dave Asprey, human performance, longevity, 3S model, brain stimulation, headroom, cognitive reserve, BDNF, lactate, Zone 2, HIIT, resistance training, blood flow restriction, sleep optimization, nootropics, creatine, nicotine, acetylcholine, supplements, ADHD, arousal curve, flow state, Formula 1, anti-aging, mitochondria, metabolism, AI and the brain, ChatGPT, digital dementia, boredom, neurogenesis, hippocampus, white matter, IGF-1, osteocalcin, alcohol and dementia, TMS, TDCS, vagal nerve stimulation, near infrared light, functional medicine, cognitive stimulation, stereotype embodiment theory 

Resources:   

• Learn More About Tommy And His Work At His Website: https://www.drtommywood.com 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 — Trailer 

01:28 — Guest Intro: Dr. Tommy Wood 

03:37 — F1 Drivers & Arousal Optimization 

09:01 — Brain Headroom & the 3S Model 

13:14 — Brain Stimulation Tech (TMS, TDCS) 

17:50 — Cognitive Decline & Aging 

20:55 — Alcohol & Brain Health 

24:10 — ADHD & Brain Chemistry 

26:53 — Nicotine & Cognitive Enhancement 

33:25 — Creatine for the Brain 

35:12 — Zone 2 vs. High-Intensity Exercise 

39:19 — Strength Training & Brain Benefits 

43:12 — Boredom & Cognitive Resilience 

45:06 — AI & Brain Health 

52:49 — Future-Proofing Your Brain 

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