Limits of the Amyloid Cascade

One possibility: a leading hypothesis pursued by researchers (and funders) was built on science that now appears to be fraudulent. Stephen Dubner speaks with the scientist and the journalist who blew the whistle.

• SOURCES:
  • Charles Piller, investigative journalist for Science, author of Doctored.
  • Matthew Schrag, associate professor of neurology at Vanderbilt University Medical Center.

• RESOURCES:
  • Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer's, by Charles Piller (2025).
  • "The brain makes a lot of waste. Now scientists think they know where it goes," by Jon Hamilton (NPR, 2024).
  • "The history of Alzheimer’s disease," by Lisa Kiani and Richard Hodson (Nature, 2024).

• EXTRAS:
  • "Can Marty Makary Fix the F.D.A.?" by Freakonomics Radio (2026).
  • "Are You Ready for the Elder Swell?" by Freakonomics Radio (2025).

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.