Is There a Limitation of Our Basic Research Knowledge?

If you have ten thousand nerons, rate, so a human brain has something like a hundred billion neurons, and you think each one as being either on or off, which is not the true thing. Nerons can be more active or less active, but just on or off. The number of possible states is two to ten thousand,. which is about the same number as ten to the one thousand, which is to say, it's one followed by a thousand zeros. It's very hard to explore that space. You really do need to have theory that drives you to say, you know, let's try this specific thing... There are at least a dozen really spectacular researchers in that

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Episode notes

Welcome back to Neurotech Pub!

This episode is part two of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhD, Mark Schnitzer, PhD, and Jacob Robinson, PhD. Last time we talked about optical recording methods, but in this episode we focus on optical stimulation methods.

Cheers!

Check out video and full transcript here: https://www.paradromics.com/podcast/episode-12-mind-control-with-lasers

00:00 | Intro

1:37 | Aspirational Papers

1:56 | Packer Lab

2:10 | What is the claustrum?

2:30 | Ian's paper (but only part of it!)

3:02 | Two-Photon Bidirectional Control and Imaging In Vivo

3:29 | Inferring Spikes from Calcium Imaging

5:45 | Neuropixels are now in humans

7:12 | Paper by Pachitariu et al

7:55 | Ian Oldenburg