Neuro Mapping & Napping
Neurotech Pub
Why do we sleep? DNA repair hypothesis
Luis outlines hypotheses for sleep functions, emphasizing DNA repair and the glymphatic/cleanup models.
Welcome back to Neurotech Pub! In this episode we’re talking about sleep–why we sleep, how sleep works on a neurophysiological level, and some of the emerging sleep technologies that are about to revolutionize this essential neural activity.
Our guests are Amy Kruse, PhD, General Partner at Prime Movers Lab, Ram Gurumoorthy, PhD, Founder and CTO of Stimscience & Somnee, and Luis de Lecea, PhD, Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine.
This episode also features a video introduction to sleep stages by Paradromics Intern Zoe Lalji. This is essential viewing if you’re unfamiliar with the stages of sleep and want to follow along later in the episode.
Cheers!
Show Notes:
00:00 | Episode intro with Matt Angle and Amy Kruse
1:07 | StimScience in Fast Company
5:05 | Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep
6:43 | Connect with Prime Movers Lab
7:01 | PML on Medium
7:45 | Introduction to Sleep Stages
References:
Check out Zoe’s nonprofit organization, ALS Heroes, and her Ted Talk
12:24 | Pulling all-nighters
12:50 | Amy Kruse, PhD
13:00 | Ram Gurumoorthy, PhD
13:07 | Stimscience, now Somnee
13:30 | Luis de Lecea, PhD
18:26 | Gordon Rule, PhD
18:40 | Knights of the Old Republic II: The Sith Lords (2004)
19:50 | Why do we sleep?
20:26 | Sleep drives metabolite clearance from the adult brain
20:35 | Sleep & DNA Repair
22:13 | Neural Activity can cause DNA damage
23:22 | Jerry Seigal
24:26 | DARPA Sleep Research
24:55 | Fur seals and sleep
25:08 | How do Whales and Dolphins Sleep Without Drowning?
25:54 | Putting Humans in Stasis Is the Best Way of Getting Us to Mars
27:36 | Sleep and Mortality
28:09 | The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices
28:27 | Giulio Tononi, MD, PhD
28:45 | Sleep, Memory, and Plasticity
28:52 | Sleep Cognition and Memory
29:00 | Sleeping up and down the phylogenetic tree
29:05 | Actually...worms do sleep
29:20 | Decoding sleep
29:36 | Fruit flies and their mini sleeps
29:44 | Mapping sleep in the brain
30:35 | Hypocretin-positive neurons
31:17 | Clearly Matt slept through his midterm... again
31:57 | The hypocretins/orexins: integrators of multiple physiological functions
32:05 | Stress-sleep interactions
33:30 | The Science of Narcolepsy
35:08 | Equivalence of sleep deprivation and intoxication | Additional reference
36:21 | Sleep Pressure: Homeostatic Sleep Drive
40:38 | EEG Visualization of electrodermal activity during sleep
44:08 | Circuitry of Sleep Stages
45:00 | Regional slow waves and spindles in human sleep | Local sleep in awake rats
48:00 | Emerging Sleep Technologies
1:00:56 | Hypothalamus and Sleep
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