Perimenopause: when proteostasis shifts

In this episode of The Optimal Protein Podcast, Vanessa Spina welcomes back leading muscle metabolism researcher Dr. Arny Ferrando for a deep dive into protein, muscle, and women's physiology across the menopause transition.

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They explore why perimenopause represents a critical turning point for whole-body protein balance, how muscle loss accelerates during midlife, and why protein quality, dosing, and movement become essential for preserving lean mass and metabolic health. Dr. Ferrando also shares insights from forthcoming research comparing animal-based and plant-based proteins, and explains why muscle is the body's primary survival tissue during stress and aging.

This conversation delivers clear, evidence-based strategies for improving body composition, fat loss, and long-term health in women. Topics include:

• Why menopause changes protein utilization and muscle retention

• Perimenopause as a muscle-critical intervention window

• Protein intake vs. protein optimization

• Essential amino acids (EAAs): when supplementation is useful

• Muscle loss, fat gain, and metabolic slowdown in midlife

• Why muscle preservation matters more than scale weight

• The role of circulation, blood flow, and resistance training

• Fat loss without muscle loss: what the science shows

• GLP-1 weight loss drugs and concerns around lean mass loss

• Emerging research on beef-based vs. plant-based proteins for women

Dr. Arny Ferrando is a world-leading researcher in human protein metabolism, muscle physiology, and aging. His work has helped define how amino acids, protein intake, and exercise influence muscle preservation, recovery, and metabolic health across the lifespan.

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The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.