The Pathogenesis of Dupatren's Contracture

Nerve injury in dupatren's surgery is an infrequent complication that occurs partly because the digital nerves can be displaced from their normal anatomic relationships by retrovascular cords. The offending cells are thought to be myofibraglass and fibroblast. Growth factors such as basic fibroblast growth factor or FGF, platelet derived growth factor or PDGF, and transforming growth factor beta or TGF beta may signal the overproduction of the myofibragellic activity of the fibroblast.