In this episode we discuss:

How the Randle Cycle actually works
Whether eating carbs and fats in the same meal causes weight gain and insulin resistance
The efficiency of using fats as a fuel vs carbohydrate
How stress impacts fuel usage in the mitochondria
How to determine the optimal amount of carbs and fats in your diet

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution here:

Timestamps:

0:00 – intro

0:53 – misconceptions regarding the Randle cycle in the alternative health world

4:57 – what is the Randle cycle?

7:06 – what most people get wrong about the Randle cycle

10:44 – fat oxidation leads to increased ROS production and a decreased NAD+/NADH ratio

16:29 – how fat oxidation inhibits the utilization of carbohydrates

21:03 – the Randle cycle shows the benefits of burning carbs for energy

25:56 – how fat oxidation inhibits the utilization of carbohydrates cont’d

26:57 – metabolic dysfunction, not glucose, drives insulin resistance and aging

32:07 – fat metabolism causes a buildup of citrate which reduces glucose uptake and utilization

38:39 – how glucose oxidation inhibits the uptake and utilization of fats

45:32 – whether you can “activate” or “deactivate” the Randle cycle

47:22 – glucose oxidation leads to an optimal NAD+/NADH ratio and decreased ROS production

52:08 – the protective effects of CO2 and why the brain can’t use fats as a fuel

53:17 – whether we should strive for metabolic flexibility

55:55 – fat metabolism and ketone production as a mechanism for energy conservation and glucose sparing

1:00:02 – insulin resistance as a state of excess fat metabolism and decreasing fat metabolism or stress hormones improves this state

1:05:28 – should we avoid eating carbs and fats together due to the Randle cycle?

1:08:08 – different cells, tissues, and organs can use different fuels at the same time

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