Starting NewLimit: Longevity Bet

Brian recounts hosting dinners, discovering epigenetic reprogramming, founding NewLimit and funding clinical progress.

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Brian Armstrong is the co-founder and CEO of Coinbase, the publicly traded cryptocurrency exchange and one of the most recognized names in the digital asset industry.

Armstrong founded Coinbase in 2012 alongside Fred Ehrsam, launching out of Y Combinator with a simple but ambitious goal: to make Bitcoin easy to buy, sell, and store for everyday people. At a time when acquiring cryptocurrency required navigating technically complex and often unreliable platforms, Coinbase offered a clean, accessible interface that brought mainstream users into the space for the first time.

Under Armstrong's leadership, Coinbase grew from a consumer-focused Bitcoin wallet into a sprawling financial infrastructure company serving retail investors, institutional clients, and developers. The company expanded to include a professional trading platform, a self-custody wallet, a layer-2 blockchain called Base, and a suite of developer APIs. In April 2021, Coinbase became the first major cryptocurrency exchange to go public in the United States, listing directly on Nasdaq in a landmark moment for the broader crypto industry.

Armstrong has been one of the most vocal advocates for bringing cryptocurrency into the mainstream, pushing for clear regulatory frameworks that he believes are essential to unlocking the full potential of a crypto-based global economy. He has been equally focused on building a company culture centered entirely on that mission, encouraging employees to leave outside politics at the door and concentrate on the work.

Beyond Coinbase, Armstrong co-founded NewLimit, a longevity biotech company focused on extending human healthspan through epigenetic reprogramming. He writes and speaks regularly about the future of money, decentralized finance, and the long-term potential of a crypto-based global economy — positioning himself not just as a company builder, but as a champion for a more open financial system.

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Chapters

(00:00:00) Crypto Power in DC

(00:00:25) Market Structure Clarity

(00:01:39) SEC Lawfare Origins

(00:05:49) Suing the Regulator

(00:09:09) Winning the SEC Case

(00:11:11) Long Term Founder Mindset