Microbiome Rhythms and Meal Timing

In this episode, I’m joined by Dr Kristen Knutson to unpack circadian health and how timing influences our metabolism, cardiovascular health, and sleep quality. We discuss the role of morning light, meal timing, exercise, and regularity, and why modern lifestyles often push our biology out of sync.

Dr Knutson also clarifies common misconceptions about melatonin, wearable sleep trackers, and what to do if you wake up in the middle of the night and struggle to fall back asleep.

What We Cover

• What circadian health is and how disruption occurs in everyday life
• Why morning light is the strongest signal for your internal clock
• Meal timing basics, including why avoiding food close to bedtime matters
• Exercise timing and the simple rule most people should follow
• Sleep health beyond hours slept: quality, timing, and regularity
• Practical strategies for waking during the night and falling back asleep

Understanding circadian rhythms can help you make small changes that support better sleep, better energy, and long-term health.

To connect with the guest, follow Dr Kristen Knutson on LinkedIn and explore her research profile via Northwestern Feinberg.

• Intro (00:00)
• America’s 24/7 Problem (02:48)
• Night Owls: Is Your Sleep Schedule Genetic? (14:04)
• Why "Catching Up" on Sleep Fails (20:00)
• How to Use Light & Melatonin (29:16)
• Meal Timing and Weight Gain (37:27
• The Best Fasting Window for Your Circadian Rhythm (43:25)
• Can Late Workouts Ruin Sleep? (48:07)
• Deep Sleep vs. REM (55:23)
• How Your Brain Fights to Recover (58:32)
• Hacks for Falling Back To Sleep Quickly (01:03:27)
• The Holy Trinity of Health: Diet, Exercise, and Sleep (01:12:00)
• One Simple Step to Start Today (01:15:56)

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Simon Hill, MSc, BSc (Hons)

• Creator of theproof.com
• Host of The Proof with Simon Hill
• Author of The Proof is in the Plants

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