Why Alzheimer’s remains unsolved

One possibility: a leading hypothesis pursued by researchers (and funders) was built on science that now appears to be fraudulent. Stephen Dubner speaks with the scientist and the journalist who blew the whistle.

• SOURCES:
  • Charles Piller, investigative journalist for Science, author of Doctored.
  • Matthew Schrag, associate professor of neurology at Vanderbilt University Medical Center.

• RESOURCES:
  • Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer's, by Charles Piller (2025).
  • "The brain makes a lot of waste. Now scientists think they know where it goes," by Jon Hamilton (NPR, 2024).
  • "The history of Alzheimer’s disease," by Lisa Kiani and Richard Hodson (Nature, 2024).

• EXTRAS:
  • "Can Marty Makary Fix the F.D.A.?" by Freakonomics Radio (2026).
  • "Are You Ready for the Elder Swell?" by Freakonomics Radio (2025).

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