Sulfation, glucuronidation and liver support

In this episode of the Thyroid Pharmacist Healing Conversations podcast, Dr. Izabella Wentz interviews researcher and Clarisen (formerly Science Mama’s HQ) co-founder Alexandra Karpova, whose personal health challenges – and her children’s struggles with mast cell activation, thyroid symptoms, chronic fatigue, and sensory issues – led her to discover the critical role of functional nutrient deficiencies in chronic illness. Alexandra shares her research on how impaired metabolic pathways, detoxification issues, childhood nutrient depletion, environmental triggers, and poor nutrient activation can create symptoms of thyroid dysfunction even when lab tests look normal.

Together, they explore the surprising connections between riboflavin, sulfation pathways, histamine intolerance, autism spectrum symptoms, mitochondrial health, and thyroid metabolism. Alexandra also discusses the emerging science behind transdermal nutrient delivery, which may offer new solutions for children and adults who can’t tolerate or absorb oral supplements.

What you’ll learn in this episode:

• Many thyroid symptoms come from deeper metabolic issues, not just the thyroid itself. Alexandra explains how impaired detoxification (like sulfation or glucuronidation), mitochondrial dysfunction, or functional nutrient deficiencies can mimic hypothyroidism – even when lab tests appear normal. These hidden blocks may lead to fatigue, temperature swings, mood changes, and sensory symptoms in both adults and children.

• Functional nutrient deficiencies often don’t appear on standard blood tests. Alexandra shares how nutrients such as B2, B6, iodine, selenium, and molybdenum may be present in the bloodstream but not utilized well by cells due to poor gut function, low stomach acid, inflammation, or impaired liver pathways. This helps explain why symptoms persist despite “normal labs.”

• Children with autism, sensory issues, or mast cell activation may have underlying metabolic disruptions. Alexandra’s story highlights how addressing nutrient imbalances, gut health, and thyroid hormone activation can support dramatic improvements in sleep, sensory processing, allergic reactions, and social and cognitive development.

• Topical (transdermal) nutrients may be game-changing for kids and adults with poor gut absorption. Alexandra describes how transdermal B2, iodine, and selenium bypass gut inflammation and low stomach acid, leading to faster improvements in energy, mood, and metabolic stability – especially for children who struggle with oral supplements.

• Histamine intolerance, anxiety, eczema, and food reactions often have biochemical root causes. B2-dependent enzymes (like DAO), infections (like H. pylori), mold, poor detox pathways, and nutrient deficiencies can drive histamine overload. Supporting these pathways can dramatically reduce symptoms like anxiety, sensory overload, and skin symptoms.

• There is hope – and simple, targeted strategies can improve complex chronic symptoms. Alexandra outlines small, consistent changes parents can make to reduce overwhelm, support metabolism, and gradually rebuild health in themselves and their children.

  
  

Tune in to learn more about how nutrition, biochemistry, and metabolic support can transform thyroid health for both children and adults.

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For the full list of resources and products mentioned in this episode, and to get the full episode transcript, see complete show notes here: https://thyroidpharmacist.com/articles/podcast/

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