CADASIL and Genetic Small-Vessel Diseases

Most people think dementia starts with memory loss. But for millions, it actually begins decades earlier: in the blood vessels.

Long before someone forgets a name or misses an appointment, the brain is being quietly damaged by high blood pressure, cholesterol imbalance, poor sleep, inflammation, and chronic stress, day after day, year after year.

This kind of damage doesn't look dramatic. There's no big stroke, no clear warning sign. It happens slowly and silently, which is why it's so often missed until it's too late.

But here's the good news: vascular dementia is one of the most preventable and manageable forms of cognitive decline. When caught early, lifestyle changes and medical interventions can help slow the onset and manage the effects.

In this episode, we explore:

• What vascular dementia and vascular cognitive impairment are, and how they differ from Alzheimer's disease
• Why most dementia cases involve both vascular damage and neurodegenerative pathology (mixed dementia)
• How blood vessel damage begins in childhood and accumulates silently for decades
• The role of high blood pressure, cholesterol, diabetes, sleep disorders, and chronic stress in damaging brain vasculature
• Why slowed thinking, movement, and processing speed are hallmark signs of vascular cognitive decline
• The critical importance of the endothelium: the thin lining of blood vessels that controls brain health
• How lifestyle factors like nutrition, exercise, sleep, and stress management protect and repair vascular health
• Why managing blood pressure early is one of the most powerful interventions for long-term brain health (and why everyone should have a blood pressure monitor at home!)
• How vascular damage can be slowed, even in midlife
• Practical steps for prevention across the lifespan, from childhood through older adulthood

Our guest for this episode is DR. COLUMBUS BATISTE, a board-certified interventional cardiologist, an incredible science communicator, and author of 'Selfish: A Cardiologist's Guide to Healing a Broken Heart'. Dr. Batiste brings deep expertise on how cardiovascular health shapes brain health, and why protecting the endothelium (the inner lining of blood vessels) is foundational to longevity. His work emphasizes that all roads to longevity are paved by the heart, and what's good for the heart is good for the brain!

'Your Brain On…' is hosted by neurologists, scientists, and public health advocates Drs. Ayesha and Dean Sherzai.

SUPPORTED BY: NEURO World, a science-based brain health community designed to help you protect your brain long before problems begin. Learn more at https://neuro.world/

'Your Brain On… Vascular Dementia' • SEASON 6 • EPISODE 8

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LINKS

Dr. Columbus Batiste: https://drbatiste.com/

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REFERENCES

Core Definitions & Diagnostic Framework

• Diagnostic and Statistical Manual of Mental Disorders (5th ed.) - American Psychiatric Publishing

• Vascular contributions to cognitive impairment and dementia - https://doi.org/10.1161/STR.0b013e3182299496

• Classifying neurocognitive disorders: The DSM-5 approach - https://doi.org/10.1038/nrneurol.2014.181

Epidemiology & Public Health Burden

• Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease - https://doi.org/10.1007/s00401-016-1571-z

• Vascular dementia - https://doi.org/10.1016/S0140-6736(15)00463-8

• Risk reduction of cognitive decline and dementia: WHO guidelines - WHO Press

Small Vessel Disease & Subcortical Vascular Dementia

• Small vessel disease: Mechanisms and clinical implications - https://doi.org/10.1016/S1474-4422(19)30079-1

• Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges - https://doi.org/10.1016/S1474-4422(10)70104-6

• The clinical importance of white matter hyperintensities on brain magnetic resonance imaging - https://doi.org/10.1136/bmj.c3666

Mixed Dementia & Alzheimer–Vascular Overlap

• Mixed brain pathologies account for most dementia cases in community-dwelling older persons - https://doi.org/10.1212/01.wnl.0000271090.28148.24

• Early role of vascular dysregulation on late-onset Alzheimer's disease - https://doi.org/10.1016/j.neurobiolaging.2016.04.009

• The pathobiology of vascular dementia - https://doi.org/10.1016/j.neuron.2013.10.008

Cerebral Amyloid Angiopathy (CAA)

• Cerebral amyloid angiopathy and Alzheimer disease—one peptide, two pathways - https://doi.org/10.1038/s41582-019-0281-2

• Emerging concepts in sporadic cerebral amyloid angiopathy - https://doi.org/10.1093/brain/awx047

Genetics, Inflammation, and Repair

• Apolipoprotein E controls cerebrovascular integrity via cyclophilin A - https://doi.org/10.1038/nature11087

• TREM2—A key player in microglial biology and Alzheimer disease - https://doi.org/10.1038/s41582-018-0072-1

Prevention & Vascular Risk Factors

• Dementia prevention, intervention, and care: 2020 report of the Lancet Commission - https://doi.org/10.1016/S0140-6736(20)30367-6

• Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease - https://doi.org/10.1038/s41582-018-0070-3

Further Reading

• The role of vascular risk factors in Alzheimer's disease - https://doi.org/10.1038/s41582-021-00530-4