Protein targets and personalization

Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman combines cutting-edge medical advancements with holistic lifestyle strategies to help men optimize testosterone, sexual health, and reproductive performance at every age. 

Together, Dave and Dr. Houman tear through the myths, the bad science, and the outdated medical dogma around testosterone, erectile function, fertility, and male sexual health. They cover everything from why testosterone levels have collapsed in a single generation, to the real story behind the FDA black box warning, to practical protocols for men who want to optimize without sacrificing fertility. This is the masterclass on men's health that no one else is having on record. 

This is essential listening for anyone serious about biohacking, longevity, human performance, hormone optimization, brain optimization, anti-aging, functional medicine, mitochondria, and Smarter Not Harder approaches to male health. 

You'll Learn: 

• Why testosterone levels in 40-year-old men are 30 percent lower than their fathers and what is driving the collapse 
• How low testosterone connects to anxiety, depression, high cholesterol, blood sugar dysregulation, and all-cause mortality risk 
• The truth about the original testosterone and heart attack study and why it still has not been retracted 
• How to preserve fertility while on TRT using Clomid, enclomiphene, and HCG 
• Why daily low-dose Cialis is one of the cheapest and most effective longevity drugs available 
• What shockwave therapy, PRP, exosomes, and Botox injections actually do for erectile function 
• How red light therapy at 660 and 850 nanometers supports testosterone production and nocturnal erections 
• The supplement stack including ashwagandha, tongkat ali, fadogia agrestis, and creatine that supports healthy hormone levels 
• Why porn-induced ED is epidemic in young men and how to reverse it 
• How PT-141 and peptides fit into a complete male optimization protocol 

Thank you to our sponsors!    

• Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference 
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• BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: testosterone, low testosterone, TRT, testosterone replacement therapy, male fertility, erectile dysfunction, ED, men's health, sexual health, hormone optimization, Dave Asprey, biohacking, longevity, anti-aging, human performance, Dr. Justin Houman, Cedars-Sinai, urologist, shockwave therapy, PRP, exosomes, Botox penis, red light therapy, nitric oxide, Cialis, tadalafil, Viagra, sildenafil, PT-141, Melanotan, peptides, ashwagandha, tongkat ali, fadogia agrestis, creatine, Danger Coffee, Smarter Not Harder, Kyzatrex, clomid, enclomiphene, HCG, prolactin, cabergoline, porn-induced ED, refractory period, fertility, sperm health, spermatogenesis, FSH, LH, estrogen, aromatization, functional medicine, supplements, mitochondria, circadian rhythm, sleep optimization, cortisol, microplastics, inflammation, cardiovascular health, dementia, all-cause mortality, nocturnal erections, penile health, male optimization 

Resources:   

• Learn More About Dr. Houman’s Work At: https://houmanmd.com/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Introduction 

01:15 – Low Testosterone Epidemic 

04:23 – Ejaculation & Testosterone 

07:30 – Refractory Period & Aging 

09:58 – Porn-Induced ED 

11:09 – Cabergoline & Prolactin Management 

12:42 – Oral Testosterone 

13:24 – Testosterone Target Levels 

16:46 – Supplements for Testosterone 

18:46 – Anxiety-Based ED 

26:23 – Penis Enhancement Options 

27:37 – Shockwave Therapy 

28:57 – Cialis for Longevity 

29:56 – Fat & Filler Injections 

34:50 – Pre-Sex Optimization 

40:13 – Red Light Therapy 

42:18 – Heat & Cold for Testosterone 

43:35 – Underwear & Microplastics 

44:58 – Testosterone & Fertility 

49:15 – HCG & Preserving Fertility 

52:00 – Testosterone Dosing Timing 

53:22 – Creatine & Mitochondrial Health 

55:20 – Overtraining Effects 

56:24 – Peptides (PT-141) 

59:08 – Optimal Diet for Fertility 

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