Rapamycin and Metformin Perspectives

Chronic inflammation, environmental toxins, and metabolic dysfunction continue to accelerate aging and chronic disease across modern populations. Many of the biggest drivers of health decline remain invisible, quietly accumulating in the body for decades before symptoms appear.

In this episode of Extend, we sit down with Dr. Terry Grossman, physician, longevity expert, and co author of Transcend and Fantastic Voyage with futurist Ray Kurzweil, to unpack the science behind therapeutic plasma exchange and its emerging role in longevity medicine. We break down how environmental toxins, microplastics, heavy metals, and chronic inflammation influence aging biology, why traditional medical testing often misses these risks, and how therapies like plasma exchange may help remove harmful compounds while improving key biomarkers linked to healthspan.

We also explore how advanced diagnostics, hormone optimization, peptide therapies, and targeted longevity protocols may help individuals move beyond disease management toward true biological optimization.

Dr. Terry Grossman is a pioneer in anti aging and longevity medicine who operates longevity clinics in Colorado and co authored two best selling books with Ray Kurzweil. He is also the author of Plasma Reset, the first book focused on therapeutic plasma exchange as a strategy for detoxification, anti aging, and long term health optimization.

What We Discuss:

• (01:54) How Dr. Terry Grossman entered longevity medicine

• (05:19) The shift from traditional care to prevention and wellness

• (12:45) The core pillars of longevity and health optimization

• (16:30) VO2 max, HRV, and modern longevity metrics

• (20:00) Genetic testing and personalized lifestyle strategies

• (22:40) Environmental toxins and the rise of microplastics

• (33:20) Simple detox strategies for daily life

• (37:55) What therapeutic plasma exchange actually does

• (46:55) Plasma exchange for toxins, autoimmunity, and long COVID

• (51:45) Senescent cells, inflammation, and biological aging

• (1:06:00) Hormone optimization and healthspan

• (1:14:20) Peptides and emerging longevity therapies

• (1:20:10) Rapamycin and metformin in longevity medicine

• (1:24:00) Foundational supplements for long term health

• (1:29:00) AI and the future of longevity medicine

• (1:34:30) Longevity escape velocity and the future of aging

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Learn more about Dr. Shah:

Website: https://www.drshah.com/

Clinic: https://www.next-health.com/

Instagram: darshanshahmd

Learn more about Dr. Terry Grossman:

website: grossmanwellness.com