PCSK9 biology and infection response

Dr. Nadir Ali is an interventional cardiologist with over 25 years of experience. He is also the chairman of the Department of Cardiology at Clear Lake Regional Medical Center. Before working as a cardiologist, he served as an assistant professor of medicine for eight years at Baylor College of Medicine in Houston, where he also received his medical training.

Time Stamps:

0:09:44  Podcast Begins

0:11:00  Lifestyle change and the power of animal foods

0:16:38  Is red meat killing us?  

0:19:32  Humans are not hebivores 

0:24:31  The problem with mainstream cardiology

0:31:03  The full story of LDL [and oxidized LDL]

0:38:22  Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a)  https://www.ahajournals.org/doi/10.1161/01.ATV.0000118012.64932.f4?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

0:43:23  Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/ 

0:43:50  Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients  https://www.sciencedirect.com/science/article/abs/pii/S0009308497000959?via%3Dihub

0:44:44  Linoleic acid is at the root of heart disease  

0:50:08  LDL and immune health

0:58:06  Genetic Assessment of Potential Long-Term On-Target Side Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibitors  https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002196

1:00:11  Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease  https://www.nejm.org/doi/full/10.1056/nejmoa1615664

1:02:05  Serious adverse events and deaths in PCSK9 inhibitor trials reported on Clinical  Trials.gov: a systematic review  https://www.tandfonline.com/doi/full/10.1080/17512433.2020.1787832

1:02:56  The dark truth of PCSK9 inhibitors

1:05:12  Metabolic health is what matters  

1:07:04  Metabolic health is what matters  

1:08:07  Let' change the paradigm!

1:13:21  Dr. Nadir Ali's health