Managing hyperhemolysis and transfusion reactions

Dale recommends avoiding transfusion when possible and using IVIG, steroids, EPO and supportive measures.

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Episode notes

In this episode of RCP Medicine Podcast, Dr Dale Seviar a Consultant Haematologist at Guy's and St Thomas' NHS Foundation Trust is welcomed by Dr Rebecca Kuruvilla, a previous RCP clinical education fellow and an ST7 Clinical Pharmacology and GIM registrar. Together, they discuss the management of sickle cell disease using a hypothetical case study, providing valuable insights and practical tips for medical professionals.

Sickle cell disease is one of the fastest growing genetic conditions that there is, and it's likely that many of you will be exposed to people living with sickle cell. This episode aims to provide a comprehensive understanding of the condition, acute complications and management strategies.

Funding

This episode was funded by Vertex Pharmaceuticals (Europe) Limited. Vertex had the opportunity to suggest the topic of this episode only, with no further involvement in its creation and elaboration, and all views and opinions expressed by the presenter and guests are solely their own.

Resources

Sickle Cell Disease - RCEMLearning

RCEM_BPG_Sickle-Cell-Disease_v3.2.pdf

Inherited anaemias: sickle cell and thalassaemia - ScienceDirect

Overview | Sickle cell disease: managing acute painful episodes in hospital | Guidance | NICE

Management of Acute Chest Syndrome in Sickle Cell Disease

Hemolytic transfusion reactions in sickle cell disease: underappreciated and potentially fatal - PMC

Sickle cell disease (SCD) and stem cell transplant | Anthony Nolan

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