Estrogen Metabolites, Phase I/II Detox Pathways

Dr. Carrie Jones explains 2/4/16 hydroxylation pathways, phase two conjugation routes, and cancer-relevant quinone formation.

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We have an estrogen masterclass mashup episode today, featuring Dr. Carrie Jones, Dr. Stephanie Estima, Dr. Sarah Berry, Dr. Thomas Dayspring, and Dr. Kellyann Niotis, who share their insights on estrogen and women’s health in midlife.

In this mashup masterclass, we’re bringing together a powerful compilation of conversations centered on the impact of hormones on brain health and cognition. We explore the nuanced risk factors for neurocognitive changes and how shifts in insulin sensitivity during perimenopause and menopause influence various aspects, including lipid patterns, hair changes, laboratory markers, and lifestyle inputs. We examine how the gut microbiome changes dynamically, targeted nutritional interventions, the role of advanced testing, including the DUTCH test, and how genetics, detoxification pathways, methylation, and the estrobolome.

This is an exciting, dynamic mashup of some of my favorite podcast conversations dedicated to estrogen and midlife physiology. It’s one you’ll likely want to revisit more than once.

IN THIS EPISODE, YOU WILL LEARN:

The critical role estrogen plays neurologically, and how estrogen receptors in the brain increase as estrogen declines
How declining estradiol during menopause impacts women's lipid metabolism
Why insulin resistance tends to increase during the menopause transition
The gut microbiome shifts that occur in postmenopausal women
The link between the gut microbiome and menopausal symptoms such as brain fog, anxiety, and sleep issues
How impaired estrogen detoxification pathways may increase long-term risk of hormone-sensitive cancers
How the DUTCH test provides insight into hormone patterns and metabolism beyond standard bloodwork
How declining estrogen disrupts the hair growth cycle and increases shedding
Why personalized approaches to supplements, diet, and HRT are essential for women in midlife

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