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Ep. 46: “Allergies and the Immune System” Featuring Dr. Caroline Sokol

The Immunology Podcast

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Mismatch Repair Deficient Cancers Respond to Checkpoint Inhibition

20 of 21 patients that had a genomic inactivation of beta two M, which is important for MHC class one presentation, were also responding to checkpoint inhibition. It feels strange because how would this response be possible if CD8s cannot see the tumors? So they they started being a little bit deeper on this on this question. And they saw there was an association between beta two M inactivation and increase infiltration by another type of T cell,. gamma delta T cells in this mismatch mismatch repair deficient cancers.

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