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#50: Andreas Horn – Toward Connectomic Deep Brain Stimulation

Stimulating Brains

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Mapping Dysfunctional Brain Circuits in Deep Brain Stimulation Research

The chapter explores the challenges and variability in patient responses to deep brain stimulation, focusing on clinical cases and a recent Nature Neuroscience paper. It discusses the concept of 'dis-spunctome,' data-driven approach, and targeting specific circuits for personalized treatments in neurological disorders. The conversation delves into advanced techniques like adaptive DBS, connectomic DBS, and using biomarkers to optimize stimulation areas, emphasizing the importance of learning from failures and maintaining a positive mindset in research.

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